Investigation of BPA Toxicity in Male New Zealand White Rabbits

The current study investigated bisphenol A (BPA) toxicity in rabbits. After the adaptation period of 2 weeks, 24 male New Zealand rabbits were equally assigned to 4 treatment groups. Corn oil was given control group, whereas 10, 20, or 100 mg/kg daily BPA corn administered remaining groups orally for 9 weeks. Throughout experiment, did not cause any clinical symptoms, and serum levels treated with elevated a dose-dependent manner. Although no effects apparent on feed intake, body weights, organ altered MDA, CAT, SOD, GPx all organs examined. Furthermore, treatments negatively affected red blood cell counts, hemoglobin, ALP, AST, ALT, CRP, amylase, creatine, urea concentrations. present concluded that LOAEL dose hematological biochemical parameters 20 mg/kg/day.